Download cardiovascular disease, genetic alterations, and gene therapy

CARDIOVASCULAR DISEASE, GENETIC ALTERATIONS, AND GENE THERAPY BY: Mary Harrell, Farah Fevrier, Kareen Carty, Daniel Omotola, and Trey Palmer

PROBLEM  With

human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?

PROBLEM 

Risk Factors For CVD – Tobacco Use – Hypertension – High Levels of Cholesterol – Physical inactivity – Diabetes – High Triglyceride Levels

– Obesity – Psychological & Social Factors – Heredity – Aging – Male – Ethnicity – Syndrome X

PROBLEM 

Risk Factors For CVD – Tobacco Use – Heredity – High Levels of Cholesterol – Physical Inactivity – Diabetes – High Triglyceride Levels

– Obesity – Psychological & Social Factors – Hypertension – Aging – Male – Ethnicity – Syndrome X

BACKGROUND INFORMATION 

Facts about Cardiovascular Disease – – – –

Mortality of CVD is 1½ times that of cancer Quality of life diminished for 25% of population Strokes account for 1/6 of all CVD hospitalizations Congestive heart failure is most frequent cause of hospital visits by people over 65 – Impact is far reaching

POSSIBLE SOLUTIONS Gene Transfer  Modification 

– – – –



Genetically defective contractile proteins Myocardial cells Cardiac protein profile to rebuild muscle Enhance contractility

Replacement – Artherosclerosis prevention



Regrowth – Alternatives to invasive surgery – Repair damaged tissue and improve heart function after infarction

BEST SOLUTION 

Regrowth with the use of Stem Cells – Proven successful on mice – Testing on non-human primates to begin – Angiogenesis “opens up” blocked vessels – Effectiveness on cardiac muscle

CONCLUSION 

With human gene mapping complete, does prevention of cardiovascular disease (CVD), the nation’s leading killer, lie within human genes?



Push for gene therapy with stem cells on humans

REFERENCES 1. 2.

Core Concepts In Health, by Insel & Roth pgs. 10, 428436, 446, 454, 483 Primary site – CVD/gene therapy paper http://oak.cats.ohiou.edu/~ed170793/paper.htm

3.

Common viriants of most human genes

www.ornl.gov/hgmis/publicat/hgn/v10n1/13lander.html 4.

Understanding DNA variations

www.ornl.gov/hgmis/publicat/hgn/v10n1/06snps.html 5.

Explaining the human genome project

www.nhgri.nih.gov/Policy_and_public_affairs/Communications/Pu blications/Maps_to_medicine/about/html

REFERENCES 6.

Angiogenesis

7.

Stem cells

8.

Gene clues and CVD

9.

Use of stem cellls on mice

www.bioportfolio.com/news/leaddiscovery_10.htm www.genome.gov/page.cfm?pageID=10000345

www.the-aps.org/press_room?release2-19-02.htm www.seniors.gov/articles/0401/heartattack